Reproduction Abstracts

Catsper is a Ca2+ permeable ion channel in the principal piece of the sperm flagellum that is crucial in regulation of motility. It is multimodally sensitive, being activated by voltage, pHi and diverse agonists including progesterone. Elevation of pHi and progesterone both shift voltage-sensitivity of the channel to more negative potentials and thus may act synergistically to enhance Ca2+-influx.1 However, intracellular alkalinisation of human...